Identification of a role for nucleolin in rabies virus infection.
J Virol
; 89(3): 1939-43, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25428867
ABSTRACT
Rabies virus replicates in the cytoplasm of host cells, but rabies virus phosphoprotein (P-protein) undergoes active nucleocytoplasmic trafficking. Here we show that the largely nuclear P-protein isoform P3 can localize to nucleoli and forms specific interactions with nucleolin. Importantly, depletion of nucleolin expression inhibits viral protein expression and infectious virus production by infected cells. This provides the first evidence that lyssaviruses interact with nucleolin and that nucleolin is important to lyssavirus infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Vírus da Raiva
/
Proteínas Estruturais Virais
/
Proteínas de Ligação a RNA
/
Interações Hospedeiro-Patógeno
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2015
Tipo de documento:
Article