Biological reaction to small-diameter vascular grafts made of silk fibroin implanted in the abdominal aortae of rats.
Ann Vasc Surg
; 29(2): 341-52, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-25449988
BACKGROUND: Bombyx mori silk fibroin (SF) is biocompatible and degradable and has been proposed as a new material for small-diameter vascular grafts. We compared biological reactions to vascular grafts made of SF and polyethylene terephthalate (PET) to reveal the potential ability of SF as a base and/or coating materials for vascular prostheses. METHODS: SF was combined with PET or gelatin (G) to make 4 types of vascular grafts (SF/SF, SF/G, PET/SF, and PET/G, shown as "base/coating material," respectively), which are 1.5 mm in diameter and 10 mm in length. The 4 types of grafts (n = 6, respectively) were implanted into rat abdominal aortae and explanted 2 weeks or 3 months later. RESULTS: Two weeks after implantation, there are no significant differences among the 4 kinds of grafts in biological reactions evaluated by histopathologic examination. However, a remarkable difference was observed after 3 months. The area of tissue infiltration into the inside of the graft wall was approximately 2.5 times larger in SF/SF than that in PET/G. The endothelialization was achieved almost 100% in SF/SF, despite only 50% was achieved in PET/G. CONCLUSIONS: Results show that SF has a higher potential as a base of vascular grafts than the commercially available PET/G graft. The larger tissue infiltration area in PET/SF compared with that in PET/G also indicates the potential of SF as a coating material. In the present study, SF delivered promising results as base and coating materials for small-diameter vascular prostheses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aorta Abdominal
/
Polietilenotereftalatos
/
Fibroínas
/
Reepitelização
Limite:
Animals
Idioma:
En
Revista:
Ann Vasc Surg
Assunto da revista:
ANGIOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Japão