Novel chemosensors for detection of glutathione by reduction or substitution of naphthalimide derivatives containing sulfoxide or sulfone substituents.
Bioorg Med Chem Lett
; 25(1): 59-61, 2015 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-25465172
ABSTRACT
A series of compounds, naphthalimide derivatives containing sulfoxide or sulfone substituents, were easily synthesized and characterized, which can be used for detection of glutathione. The detailed spectral studies demonstrated that the compounds displayed high selectivity for glutathione over cysteine, homocysteine and other biological molecules. Further studies suggested that reduction or nucleophilic substitution of sulfoxide or sulfone substituents of naphthalimide compounds by thiols induced ICT process in the chemosensors, and then resulted in fluorescence intensity enhancement. Also, the compounds were proved to be useful for imaging GSH in living cells. The nucleophilic substitution mechanism further revealed that the compounds were potential reagents for labeling sulfhydryl protein.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfonas
/
Sulfóxidos
/
Naftalimidas
/
Corantes Fluorescentes
/
Glutationa
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2015
Tipo de documento:
Article