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Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants.
Pelizzo, Gloria; Mimmi, Maria Chiara; Ballico, Maurizio; Marotta, Mario; Goruppi, Ilaria; Peiro, Jose Louis; Zambaiti, Elisa; Costanzo, Federico; Andreatta, Erika; Tonin, Elena; Calcaterra, Valeria.
Afiliação
  • Pelizzo G; a Department of the Mother and Child Health, Pediatric Surgery Unit , IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia , Pavia , Italy .
  • Mimmi MC; b Department of Medical and Biological Sciences , University of Udine , Udine , Italy .
  • Ballico M; b Department of Medical and Biological Sciences , University of Udine , Udine , Italy .
  • Marotta M; c Cincinnati Fetal Center, Pediatric Surgery Division, CCHMC , Cincinnati , OH , USA .
  • Goruppi I; d Fetal Surgery Program, Congenital Malformations Research Group, Research Institute of Hospital Universitari Vall d'Hebron , Edifici Infantil , Barcelona , Spain .
  • Peiro JL; a Department of the Mother and Child Health, Pediatric Surgery Unit , IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia , Pavia , Italy .
  • Zambaiti E; c Cincinnati Fetal Center, Pediatric Surgery Division, CCHMC , Cincinnati , OH , USA .
  • Costanzo F; d Fetal Surgery Program, Congenital Malformations Research Group, Research Institute of Hospital Universitari Vall d'Hebron , Edifici Infantil , Barcelona , Spain .
  • Andreatta E; a Department of the Mother and Child Health, Pediatric Surgery Unit , IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia , Pavia , Italy .
  • Tonin E; a Department of the Mother and Child Health, Pediatric Surgery Unit , IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia , Pavia , Italy .
  • Calcaterra V; a Department of the Mother and Child Health, Pediatric Surgery Unit , IRCCS Policlinico San Matteo Foundation Pavia and University of Pavia , Pavia , Italy .
J Matern Fetal Neonatal Med ; 29(1): 143-7, 2016.
Article em En | MEDLINE | ID: mdl-25471172
ABSTRACT

BACKGROUND:

The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.

METHODS:

Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution (1)H NMR-spectroscopy.

RESULTS:

Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.

CONCLUSIONS:

Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anormalidades do Sistema Respiratório / Pulmão Tipo de estudo: Screening_studies Limite: Humans / Infant / Male / Newborn Idioma: En Revista: J Matern Fetal Neonatal Med Assunto da revista: OBSTETRICIA / PERINATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Itália
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anormalidades do Sistema Respiratório / Pulmão Tipo de estudo: Screening_studies Limite: Humans / Infant / Male / Newborn Idioma: En Revista: J Matern Fetal Neonatal Med Assunto da revista: OBSTETRICIA / PERINATOLOGIA Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Itália