Congenital pulmonary malformations: metabolomic profile of lung phenotype in infants.
J Matern Fetal Neonatal Med
; 29(1): 143-7, 2016.
Article
em En
| MEDLINE
| ID: mdl-25471172
ABSTRACT
BACKGROUND:
The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.METHODS:
Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution (1)H NMR-spectroscopy.RESULTS:
Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.CONCLUSIONS:
Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anormalidades do Sistema Respiratório
/
Pulmão
Tipo de estudo:
Screening_studies
Limite:
Humans
/
Infant
/
Male
/
Newborn
Idioma:
En
Revista:
J Matern Fetal Neonatal Med
Assunto da revista:
OBSTETRICIA
/
PERINATOLOGIA
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Itália