Advances in synapse formation: forging connections in the worm.
Wiley Interdiscip Rev Dev Biol
; 4(2): 85-97, 2015.
Article
em En
| MEDLINE
| ID: mdl-25472860
ABSTRACT
UNLABELLED Synapse formation is the quintessential process by which neurons form specific connections with their targets to enable the development of functional circuits. Over the past few decades, intense research efforts have identified thousands of proteins that localize to the pre- and postsynaptic compartments. Genetic dissection has provided important insights into the nexus of the molecular and cellular network, and has greatly advanced our knowledge about how synapses form and function physiologically. Moreover, recent studies have highlighted the complex regulation of synapse formation with the identification of novel mechanisms involving cell interactions from non-neuronal sources. In this review, we cover the conserved pathways required for synaptogenesis and place specific focus on new themes of synapse modulation arising from studies in Caenorhabditis elegans. For further resources related to this article, please visit the WIREs website. CONFLICT OF INTEREST The authors have declared no conflicts of interest for this article.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Caenorhabditis elegans
Limite:
Animals
Idioma:
En
Revista:
Wiley Interdiscip Rev Dev Biol
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos