Two new coumarins from Talaromyces flavus.
Molecules
; 19(12): 20880-7, 2014 Dec 12.
Article
em En
| MEDLINE
| ID: mdl-25514227
ABSTRACT
Two new coumarins, talacoumarins A (1) and B (2), were isolated from the ethyl acetate extract of the wetland soil-derived fungus Talaromyces flavus BYD07-13. Their structures were elucidated by spectroscopic data (NMR, MS) analyses. The absolute configuration of C-12 in 1 was assigned using the modified Mosher's method, whereas that of C-12 in 2 was deduced via the circular dichroism data of its corresponding [Rh2(OCOCF3)4] complex. Compounds 1 and 2 were evaluated for their anti-Aß42 aggregation, cytotoxic, and antimicrobial activities. The results showed that the two compounds had moderate anti-Aß42 aggregation activity, and this is the first report on the Aß42 inhibitory aggregation activity of coumarins.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cumarínicos
/
Talaromyces
Limite:
Humans
Idioma:
En
Revista:
Molecules
Assunto da revista:
BIOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
China