Resemble and Inhibit: when RLR meets TGF-ß.

Zhu, Shu; Li, Hua-Bing; Flavell, Richard A

Zhu, Shu; Li, Hua-Bing; Flavell, Richard A.

Afiliação

Zhu S; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Li HB; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Flavell RA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA. Electronic address: richard.flavell@yale.edu.

Mol Cell ; 56(6): 719-20, 2014 Dec 18.

Article em En | MEDLINE | ID: mdl-25526529

RESUMO

In this issue, Xu et al. (2014) show that innate antiviral RIG-I-like receptors (RLR) signaling represses TGF-ß-induced growth inhibition, epithelial-mesenchyme transition (EMT), and regulatory T cell (Treg) differentiation via IRF3-mediated Smads function.

Assuntos

Fator Regulador 3 de Interferon/fisiologia; Vírus Sendai/imunologia; Proteína Smad3/metabolismo; Fator de Crescimento Transformador beta/fisiologia; Animais; Humanos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Crescimento Transformador beta / Vírus Sendai / Fator Regulador 3 de Interferon / Proteína Smad3 Limite: Animals / Humans Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Estados Unidos

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