Your browser doesn't support javascript.
loading
Sensitivity of pharmacokinetic-pharmacodynamic analysis for detecting small magnitudes of QTc prolongation in preclinical safety testing.
Gotta, Verena; Cools, Frank; van Ammel, Karel; Gallacher, David J; Visser, Sandra A G; Sannajust, Frederick; Morissette, Pierre; Danhof, Meindert; van der Graaf, Piet H.
Afiliação
  • Gotta V; Systems Pharmacology, Leiden Academic Center of Drug Research (LACDR), Leiden University, Leiden, The Netherlands. Electronic address: v.gotta@lacdr.leidenuniv.nl.
  • Cools F; Global Safety Pharmacology, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium. Electronic address: fcools@its.jnj.com.
  • van Ammel K; Global Safety Pharmacology, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium. Electronic address: kvammel@its.jnj.com.
  • Gallacher DJ; Global Safety Pharmacology, Janssen Research & Development, Janssen Pharmaceutica NV, Beerse, Belgium. Electronic address: dgallach@its.jnj.com.
  • Visser SA; Quantitative Pharmacology and Pharmacometrics, Merck Research Laboratories, Merck & Co., Inc., Upper Gwynedd, PA, USA. Electronic address: sandra.visser@merck.com.
  • Sannajust F; SALAR, Safety and Exploratory Pharmacology Department, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, USA. Electronic address: frederick.sannajust@merck.com.
  • Morissette P; SALAR, Safety and Exploratory Pharmacology Department, Merck Research Laboratories, Merck & Co., Inc., West Point, PA, USA. Electronic address: pierre_morissette@merck.com.
  • Danhof M; Systems Pharmacology, Leiden Academic Center of Drug Research (LACDR), Leiden University, Leiden, The Netherlands. Electronic address: m.danhof@lacdr.leidenuniv.nl.
  • van der Graaf PH; Systems Pharmacology, Leiden Academic Center of Drug Research (LACDR), Leiden University, Leiden, The Netherlands. Electronic address: p.vandergraaf@lacdr.leidenuniv.nl.
J Pharmacol Toxicol Methods ; 72: 1-10, 2015.
Article em En | MEDLINE | ID: mdl-25556117
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Sotalol / Doenças do Cão / Antiarrítmicos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: J Pharmacol Toxicol Methods Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Sotalol / Doenças do Cão / Antiarrítmicos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: J Pharmacol Toxicol Methods Assunto da revista: FARMACOLOGIA / TOXICOLOGIA Ano de publicação: 2015 Tipo de documento: Article