Silibinin Prevents Autophagic Cell Death upon Oxidative Stress in Cortical Neurons and Cerebral Ischemia-Reperfusion Injury.

Wang, Min; Li, Yu-Jiao; Ding, Yi; Zhang, Hui-Nan; Sun, Ting; Zhang, Kun; Yang, Le; Guo, Yan-Yan; Liu, Shui-Bing; Zhao, Ming-Gao; Wu, Yu-Mei

Wang, Min; Li, Yu-Jiao; Ding, Yi; Zhang, Hui-Nan; Sun, Ting; Zhang, Kun; Yang, Le; Guo, Yan-Yan; Liu, Shui-Bing; Zhao, Ming-Gao; Wu, Yu-Mei.

Afiliação

Wang M; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, People's Republic of China.
Li YJ; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, People's Republic of China.
Ding Y; Department of Pharmacy, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, People's Republic of China.
Zhang HN; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, People's Republic of China.
Sun T; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, People's Republic of China.
Zhang K; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, People's Republic of China.
Yang L; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, People's Republic of China.
Guo YY; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, People's Republic of China.
Liu SB; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, People's Republic of China.
Zhao MG; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, People's Republic of China. minggao@fmmu.edu.cn.
Wu YM; Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi Province, 710032, People's Republic of China. yumeiwu@fmmu.edu.cn.

Mol Neurobiol ; 53(2): 932-943, 2016 Mar.

Article em En | MEDLINE | ID: mdl-25561437

Assuntos

Autofagia/efeitos dos fármacos; Isquemia Encefálica/tratamento farmacológico; Córtex Cerebral/patologia; Neurônios/patologia; Estresse Oxidativo/efeitos dos fármacos; Traumatismo por Reperfusão/tratamento farmacológico; Silimarina/uso terapêutico; Animais; Apoptose/efeitos dos fármacos; Isquemia Encefálica/complicações; Isquemia Encefálica/patologia; Sobrevivência Celular/efeitos dos fármacos; Células Cultivadas; Peróxido de Hidrogênio/toxicidade; Infarto da Artéria Cerebral Média/complicações; Infarto da Artéria Cerebral Média/patologia; Masculino; Camundongos Endogâmicos C57BL; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Neuroproteção/efeitos dos fármacos; Fármacos Neuroprotetores/farmacologia; Fármacos Neuroprotetores/uso terapêutico; Fosfatidilinositol 3-Quinases/metabolismo; Fosforilação/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-akt/metabolismo; Traumatismo por Reperfusão/complicações; Traumatismo por Reperfusão/patologia; Silibina; Silimarina/química; Silimarina/farmacologia

Palavras-chave

Antioxidant; Apoptosis; Autophagy; Neuron; Oxidative stress; Silibinin; Survival

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Silimarina / Autofagia / Traumatismo por Reperfusão / Córtex Cerebral / Isquemia Encefálica / Estresse Oxidativo / Neurônios Limite: Animals Idioma: En Revista: Mol Neurobiol Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2016 Tipo de documento: Article

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