Association of variation range in glycated albumin (GA) with increase but not decrease in plasma glucose: implication for the mechanism by which GA reflects glycemic excursion.
Clin Biochem
; 48(6): 397-400, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25562185
ABSTRACT
OBJECTIVES:
HbA1c mainly reflects mean plasma glucose (PG), whereas glycated albumin (GA) reflects glycemic excursion in addition to mean PG; the mechanism of the difference between HbA1c and GA is unknown. We hypothesized that a transient increase in PG irreversibly produces stable GA unlike HbA1c. To prove this hypothesis, we investigated diurnal variations in PG, HbA1c, #C fraction (a fraction containing unstable HbA1c and modified hemoglobin on HPLC) and GA in diabetic patients. DESIGN ANDMETHODS:
Sixteen diabetic patients with poor glycemic control were enrolled in this study. Blood sampling was performed before and after each meal, before bedtime, and before breakfast on the following day; PG, HbA1c, #C fraction, and GA were measured. The variations of these indicators were compared with those in PG.RESULTS:
HbA1c showed almost no change regardless of diurnal glycemic variation. Variation range in #C fraction significantly correlated with variation range in PG when PG increased (R=0.746, p<0.0001) and decreased (R=0.271, p=0.035). On the other hand, variation range in GA significantly correlated with variation range in PG when PG increased (R=0.322, p=0.021), but not when PG decreased (R=0.090, p=0.493).CONCLUSIONS:
We observed that variation range in GA significantly correlated with variation range in PG when PG increased but not when PG decreased for the first time. It is considered that GA reflects glycemic excursion through this phenomenon.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemoglobinas Glicadas
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Diabetes Mellitus Tipo 1
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Diabetes Mellitus Tipo 2
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Clin Biochem
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Japão