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A genome-wide association study of marginal zone lymphoma shows association to the HLA region.
Vijai, Joseph; Wang, Zhaoming; Berndt, Sonja I; Skibola, Christine F; Slager, Susan L; de Sanjose, Silvia; Melbye, Mads; Glimelius, Bengt; Bracci, Paige M; Conde, Lucia; Birmann, Brenda M; Wang, Sophia S; Brooks-Wilson, Angela R; Lan, Qing; de Bakker, Paul I W; Vermeulen, Roel C H; Portlock, Carol; Ansell, Stephen M; Link, Brian K; Riby, Jacques; North, Kari E; Gu, Jian; Hjalgrim, Henrik; Cozen, Wendy; Becker, Nikolaus; Teras, Lauren R; Spinelli, John J; Turner, Jenny; Zhang, Yawei; Purdue, Mark P; Giles, Graham G; Kelly, Rachel S; Zeleniuch-Jacquotte, Anne; Ennas, Maria Grazia; Monnereau, Alain; Bertrand, Kimberly A; Albanes, Demetrius; Lightfoot, Tracy; Yeager, Meredith; Chung, Charles C; Burdett, Laurie; Hutchinson, Amy; Lawrence, Charles; Montalvan, Rebecca; Liang, Liming; Huang, Jinyan; Ma, Baoshan; Villano, Danylo J; Maria, Ann; Corines, Marina.
Afiliação
  • Vijai J; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
  • Wang Z; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.
  • Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
  • Skibola CF; 1] Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, Alabama 35233, USA [2] Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California 94720, USA.
  • Slager SL; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.
  • de Sanjose S; 1] Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, IDIBELL, Barcelona 8907, Spain [2] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Barcelona 8036, Spain.
  • Melbye M; 1] Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark [2] Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
  • Glimelius B; 1] Department of Oncology and Pathology, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm 17176, Sweden [2] Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala 75105, Sweden.
  • Bracci PM; Department of Epidemiology &Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.
  • Conde L; 1] Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, Alabama 35233, USA [2] Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California 94720, USA.
  • Birmann BM; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Wang SS; Department of Cancer Etiology, City of Hope Beckman Research Institute, Duarte, California 91030, USA.
  • Brooks-Wilson AR; 1] Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3 [2] Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada V5A1S6.
  • Lan Q; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
  • de Bakker PI; 1] Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht 3584 CG, The Netherlands [2] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.
  • Vermeulen RC; 1] Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands [2] Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, The Netherlands.
  • Portlock C; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
  • Ansell SM; Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
  • Link BK; Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.
  • Riby J; 1] Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, Birmingham, Alabama 35233, USA [2] Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California 94720, USA.
  • North KE; 1] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA [2] Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • Gu J; Department of Epidemiology, M.D. Anderson Cancer Center, Houston, Texas 77030, USA.
  • Hjalgrim H; Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, Copenhagen 2300, Denmark.
  • Cozen W; 1] Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA [2] Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.
  • Becker N; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
  • Teras LR; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.
  • Spinelli JJ; 1] Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3 [2] School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada V6T1Z3.
  • Turner J; 1] Pathology, Australian School of Advanced Medicine, Macquarie University, Sydney, New South Wales 2109, Australia [2] Department of Histopathology, Douglass Hanly Moir Pathology, Macquarie Park, New South Wales 2113, Australia.
  • Zhang Y; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.
  • Purdue MP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
  • Giles GG; 1] Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3053, Australia [2] Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Carlton, Victoria 3010, Australia.
  • Kelly RS; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
  • Zeleniuch-Jacquotte A; 1] Department of Population Health, New York University School of Medicine, New York, New York 10016, USA [2] Cancer Institute, New York University School of Medicine, New York, New York 10016, USA.
  • Ennas MG; Department of Biomedical Science, University of Cagliari, Monserrato, Cagliari 09042, Italy.
  • Monnereau A; 1] Environmental Epidemiology of Cancer Group, Inserm, Centre for research in Epidemiology and Population Health (CESP), U1018, Villejuif F-94807, France [2] UMRS 1018, Univ Paris Sud, Villejuif F-94807, France [3] Registre des hémopathies malignes de la Gironde, Institut Bergonié, Bordeaux 33076, F
  • Bertrand KA; 1] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA [2] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
  • Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
  • Lightfoot T; Department of Health Sciences, University of York, York YO10 5DD, UK.
  • Yeager M; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.
  • Chung CC; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.
  • Burdett L; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.
  • Hutchinson A; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.
  • Lawrence C; Health Studies Sector, Westat, Rockville, Maryland 20850, USA.
  • Montalvan R; Health Studies Sector, Westat, Rockville, Maryland 20850, USA.
  • Liang L; 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA [2] Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
  • Huang J; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
  • Ma B; 1] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA [2] College of Information Science and Technology, Dalian Maritime University, Dalian 116026, China.
  • Villano DJ; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
  • Maria A; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
  • Corines M; Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Nat Commun ; 6: 5751, 2015 Jan 08.
Article em En | MEDLINE | ID: mdl-25569183
ABSTRACT
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Linfoma de Zona Marginal Tipo Células B / Polimorfismo de Nucleotídeo Único / População Branca / Complexo Principal de Histocompatibilidade Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Linfoma de Zona Marginal Tipo Células B / Polimorfismo de Nucleotídeo Único / População Branca / Complexo Principal de Histocompatibilidade Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos