Early experience with intensity modulated proton therapy for lung-intact mesothelioma: A case series.
Pract Radiat Oncol
; 5(4): e345-53, 2015.
Article
em En
| MEDLINE
| ID: mdl-25572666
ABSTRACT
PURPOSE:
The purpose of this study was to describe our experience implementing intensity modulated proton therapy (IMPT) for lung-intact malignant pleural mesothelioma (MPM), including patient selection, treatment planning, dose verification, and process optimization. METHODS AND MATERIALS Seven patients with epithelioid MPM were reviewed; 6 underwent pleurectomy, whereas 1 had biopsy alone. Four patients received IMPT and 3 received intensity modulated radiation therapy. Treatment plans for the other modality were created for dosimetric comparisons. Quality assurance processes included dose verification and robustness analysis. Image-guided setup was performed with the first isocenter, and couch shifts were applied to reposition to the second isocenter.RESULTS:
Treatment with IMPT was well tolerated and completed without breaks. IMPT plans were designed with 2 isocenters, 4 beams, and ≤64 energy layers per beam. Dose verification processes were completed in 3 hours. Total daily treatment time was approximately 45 minutes (20 minutes for setup and 25 minutes for delivery). IMPT produced lower mean doses to the contralateral lung, heart, esophagus, liver, and ipsilateral kidney, with increased contralateral lung sparing when mediastinal boost was required for nodal disease.CONCLUSIONS:
Our initial experience showed that IMPT was feasible for routine care of patients with lung-intact MPM.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Radioterapia de Intensidade Modulada
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Radioterapia Guiada por Imagem
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Neoplasias Pulmonares
/
Mesotelioma
Tipo de estudo:
Observational_studies
Limite:
Aged
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Pract Radiat Oncol
Ano de publicação:
2015
Tipo de documento:
Article