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Subclinical carotid atherosclerosis in elderly patients with primary Sjögren syndrome: a duplex Doppler sonographic study.
Zardi, E M; Sambataro, G; Basta, F; Margiotta, D P E; Afeltra, A M V.
Afiliação
  • Zardi EM; Department of Clinical Medicine and Rheumatology, University Campus Bio-Medico of Rome, Rome, Italy.
  • Sambataro G; Department of Clinical Medicine and Rheumatology, University Campus Bio-Medico of Rome, Rome, Italy.
  • Basta F; Department of Clinical Medicine and Rheumatology, University Campus Bio-Medico of Rome, Rome, Italy.
  • Margiotta DP; Department of Clinical Medicine and Rheumatology, University Campus Bio-Medico of Rome, Rome, Italy.
  • Afeltra AM; Department of Clinical Medicine and Rheumatology, University Campus Bio-Medico of Rome, Rome, Italy.
Int J Immunopathol Pharmacol ; 27(4): 645-51, 2014.
Article em En | MEDLINE | ID: mdl-25572746
ABSTRACT
A growing body of evidence presents a link between chronic inflammatory rheumatic diseases and atherosclerosis. To evaluate subclinical carotid atherosclerosis in an elderly group of patients with primary Sjögren syndrome compared with a control group matched for age, sex, ethnicity and cardiovascular risk factors, we enrolled 18 patients with Primary Sjögren Syndrome (mean age 65 ± 5.93 SD) and 18 mild Ostheoarthritic patients (mean age 66 ± 5.94 SD) from the outpatient department of Rheumatology, University “Campus Bio-Medico, Rome, Italy, matched for age, sex, ethnicity and cardiovascular risk factors. A duplex Doppler sonographic study of carotids was performed in order to evaluate intima-media thickness (IMT), stiffness and haemodynamic parameters [resistivity and pulsatility indices (RI and PI, respectively)]. No significant difference was found between primary Sjögren syndrome and control patients in IMT, stiffness and haemodynamic parameters. The lack of significant difference in subclinical atherosclerosis between elderly primary Sjögren syndrome and control matched patients, indicates that traditional cardiovascular risk factors, immunologic alterations and chronic inflammation do not influence the progression of vascular damage in the carotid circulation of patients with median disease duration of 6.5 years.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças das Artérias Carótidas / Síndrome de Sjogren / Ultrassonografia Doppler Dupla Tipo de estudo: Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Int J Immunopathol Pharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA / PATOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Itália
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças das Artérias Carótidas / Síndrome de Sjogren / Ultrassonografia Doppler Dupla Tipo de estudo: Risk_factors_studies Limite: Aged / Aged80 / Female / Humans / Male Idioma: En Revista: Int J Immunopathol Pharmacol Assunto da revista: ALERGIA E IMUNOLOGIA / FARMACOLOGIA / PATOLOGIA Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Itália