Cumulative Metformin Use and Its Impact on Survival in Gastric Cancer Patients After Gastrectomy.
Ann Surg
; 263(1): 96-102, 2016 Jan.
Article
em En
| MEDLINE
| ID: mdl-25575260
ABSTRACT
OBJECTIVE:
The aim of this study was to evaluate the association between metformin and survival of gastric cancer (GC) patients.BACKGROUND:
Metformin has recently received attention as a potential anticancer treatment. However, no study has shown the survival benefit of metformin for GC patients.METHODS:
A total of 1974 GC patients who underwent curative gastrectomy were compared for survival according to groups; 132 diabetic patients treated with metformin, 194 diabetic patients without metformin, and 1648 non-diabetic patients.RESULTS:
During the median follow-up period of 6.2 years (interquartile range, 4.7-7.8 years), 381 patients (19.3%) died, including 302 (15.3%) who died from GC. The non-diabetic patients had significantly better recurrence-free survival (RFS; P < 0.0001), cancer-specific survival (CSS; P = 0.006), and overall survival (OS; P < 0.0001). However, the diabetic patients treated with metformin had a significantly better prognosis than those who were not (OS hazard ratio [HR] = 0.584, 95% confidence interval [CI], 0.369-0.926; CSS HR = 0.57, 95% CI, 0.334-0.975; RFS HR = 0.633, 95% CI, 0.410-0.977), and metformin treatment prolonged survival in diabetic patients to a rate comparable to that in non-diabetic patients. In multivariable analysis using the Cox proportional hazard model with time-dependent covariates, each cumulative 6 months of metformin use was significantly associated with a decreased risk of recurrence, cancer-specific mortality, and all-cause mortality (RFS HR = 0.864, 95% CI, 0.797-0.937; CSS HR = 0.865, 95% CI, 0.782-0.958; OS HR 0.870, 95% CI, 0.801-0.945).CONCLUSIONS:
The increased cumulative duration of metformin use decreased the recurrence, all-cause mortality, and cancer-specific mortality rates among GC patients with diabetes who underwent gastrectomy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Complicações do Diabetes
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Gastrectomia
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Hipoglicemiantes
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Metformina
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Surg
Ano de publicação:
2016
Tipo de documento:
Article