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Design, synthesis and pharmacological evaluation of novel N-(2-(1, 1-dimethyl-5, 7-dioxo-4, 6-diazaspiro[2.4]heptan-6-yl)ethyl) sulfonamide derivatives as potential anticonvulsant agents.
Li, Jinping; Lou, Jun; Wang, Zhiming; Wang, Ting; Xiao, Yuling; Hu, Xianming; Liu, Peng; Hong, Xuechuan.
Afiliação
  • Li J; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, 430071, PR China.
  • Lou J; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, 430071, PR China.
  • Wang Z; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, 430071, PR China.
  • Wang T; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, 430071, PR China.
  • Xiao Y; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, 430071, PR China.
  • Hu X; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, 430071, PR China.
  • Liu P; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, 430071, PR China.
  • Hong X; State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, 430071, PR China. Electronic address: xhy78@whu.edu.cn.
Eur J Med Chem ; 92: 370-6, 2015 Mar 06.
Article em En | MEDLINE | ID: mdl-25585007
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convulsões / Compostos de Espiro / Desenho de Fármacos / Cicloeptanos / Anticonvulsivantes Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Convulsões / Compostos de Espiro / Desenho de Fármacos / Cicloeptanos / Anticonvulsivantes Limite: Animals Idioma: En Revista: Eur J Med Chem Ano de publicação: 2015 Tipo de documento: Article