Kidney transplant recipients carrying the CYP3A4*22 allelic variant have reduced tacrolimus clearance and often reach supratherapeutic tacrolimus concentrations.

Pallet, N; Jannot, A-S; El Bahri, M; Etienne, I; Buchler, M; de Ligny, B H; Choukroun, G; Colosio, C; Thierry, A; Vigneau, C; Moulin, B; Le Meur, Y; Heng, A-E; Subra, J-F; Legendre, C; Beaune, P; Alberti, C; Loriot, M A; Thervet, E

Pallet, N; Jannot, A-S; El Bahri, M; Etienne, I; Buchler, M; de Ligny, B H; Choukroun, G; Colosio, C; Thierry, A; Vigneau, C; Moulin, B; Le Meur, Y; Heng, A-E; Subra, J-F; Legendre, C; Beaune, P; Alberti, C; Loriot, M A; Thervet, E.

Afiliação

Pallet N; Clinical Chemistry, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France; Department of Nephrology, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France; Paris Descartes University, Paris, France; Sorbonne Paris Cité, INSERM UMRS, 1147, Paris, France.

Am J Transplant ; 15(3): 800-5, 2015 Mar.

Article em En | MEDLINE | ID: mdl-25588704

Assuntos

Alelos; Citocromo P-450 CYP3A/genética; Imunossupressores/farmacocinética; Transplante de Rim; Tacrolimo/farmacocinética; Adulto; Feminino; Humanos; Masculino; Pessoa de Meia-Idade

Palavras-chave

Clinical research; immune modulation; immunosuppressant, calcineurin inhibitor: tacrolimus, pharmacokinetics; nephrology, immunosuppression; pharmacodynamics, genetics; pharmacology, kidney transplantation; practice

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Rim / Tacrolimo / Alelos / Citocromo P-450 CYP3A / Imunossupressores Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Transplant Assunto da revista: TRANSPLANTE Ano de publicação: 2015 Tipo de documento: Article País de afiliação: França

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