Complete assignments of NMR data and assessment of trypanocidal activity of new eremantholide C derivatives.
An Acad Bras Cienc
; 86(4): 1563-72, 2014 Dec.
Article
em En
| MEDLINE
| ID: mdl-25590700
ABSTRACT
Chemical transformations of eremantholide C (1), a sesquiterpene lactone that was isolated from Lychnophora trichocarpha Spreng. led to five new derivatives 1',2'- epoxyeremantholide C (2), 5-n-propylamine-4,5-dihydro-1',2'-epoxyeremantholide C (3), 5-n-propylammonium-4,5-dihydro-1',2'-epoxyeremantholide C chloride (4), 5-n-propylammonium-4,5-dihydroeremantolide C chloride (5) and 16-O-ethyleremantholide C (6). The structures of all these derivatives were assigned on the basis of IR, MS, 1H and 13C NMR data by 1D and 2D techniques. Eremantholide C and the derivatives 2, 4 and 5 were evaluated against trypomastigotes Y and CL strains of Trypanosoma cruzi. Eremantholide C completely inhibited the growth of both the parasites strains while all derivatives were partially active against the CL strain and inactive against the Y strain.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Trypanosoma cruzi
/
Extratos Vegetais
/
Asteraceae
Idioma:
En
Revista:
An Acad Bras Cienc
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Brasil