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Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation.
Westenbrink, B Daan; Ling, Haiyun; Divakaruni, Ajit S; Gray, Charles B B; Zambon, Alexander C; Dalton, Nancy D; Peterson, Kirk L; Gu, Yusu; Matkovich, Scot J; Murphy, Anne N; Miyamoto, Shigeki; Dorn, Gerald W; Heller Brown, Joan.
Afiliação
  • Westenbrink BD; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
  • Ling H; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
  • Divakaruni AS; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
  • Gray CB; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
  • Zambon AC; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
  • Dalton ND; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
  • Peterson KL; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
  • Gu Y; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
  • Matkovich SJ; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
  • Murphy AN; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
  • Miyamoto S; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
  • Dorn GW; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
  • Heller Brown J; From the Department of Pharmacology (B.D.W., H.L., A.S.D., C.B.B.G., A.C.Z., A.N.M., J.H.B.), Department of Medicine (N.D.D., K.L.P., Y.G.), and Biomedical Sciences Graduate Program (C.B.B.G.), University of California San Diego; School of Internal Medicine, Center for Pharmacogenomics, Washington U
Circ Res ; 116(5): e28-39, 2015 Feb 27.
Article em En | MEDLINE | ID: mdl-25605649
Assuntos
Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/fisiologia; Cardiomegalia/enzimologia; Cardiomiopatia Dilatada/etiologia; Insuficiência Cardíaca/etiologia; Mitocôndrias Cardíacas/fisiologia; Acetilcisteína/farmacologia; Animais; Apoptose; Benzilaminas/farmacologia; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/deficiência; Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/genética; Cardiomegalia/fisiopatologia; Cardiomiopatia Dilatada/fisiopatologia; Cardiomiopatia Dilatada/prevenção & controle; Células Cultivadas; Progressão da Doença; Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP/deficiência; Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP/genética; Subunidades alfa Gq-G11 de Proteínas de Ligação ao GTP/fisiologia; Perfilação da Expressão Gênica; Insuficiência Cardíaca/fisiopatologia; Canais Iônicos/biossíntese; Canais Iônicos/genética; Canais Iônicos/fisiologia; Masculino; Camundongos; Camundongos Knockout; Camundongos Transgênicos; Proteínas Mitocondriais/biossíntese; Proteínas Mitocondriais/genética; Proteínas Mitocondriais/fisiologia; Miócitos Cardíacos/metabolismo; Estresse Oxidativo; PPAR alfa/biossíntese; PPAR alfa/genética; Mutação Puntual; Pressão; Interferência de RNA; RNA Mensageiro/biossíntese; RNA Mensageiro/genética; RNA Interferente Pequeno/farmacologia; Ratos; Espécies Reativas de Oxigênio; Análise de Sequência de RNA; Sulfonamidas/farmacologia; Transfecção; Proteína Desacopladora 3
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Dilatada / Cardiomegalia / Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina / Insuficiência Cardíaca / Mitocôndrias Cardíacas Idioma: En Revista: Circ Res Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia Dilatada / Cardiomegalia / Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina / Insuficiência Cardíaca / Mitocôndrias Cardíacas Idioma: En Revista: Circ Res Ano de publicação: 2015 Tipo de documento: Article