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BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model.
Perna, Daniele; Karreth, Florian A; Rust, Alistair G; Perez-Mancera, Pedro A; Rashid, Mamunur; Iorio, Francesco; Alifrangis, Constantine; Arends, Mark J; Bosenberg, Marcus W; Bollag, Gideon; Tuveson, David A; Adams, David J.
Afiliação
  • Perna D; Experimental Cancer Genetics and Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom;
  • Karreth FA; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom;
  • Rust AG; Experimental Cancer Genetics and.
  • Perez-Mancera PA; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom;
  • Rashid M; Experimental Cancer Genetics and.
  • Iorio F; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;
  • Alifrangis C; Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, United Kingdom;
  • Arends MJ; University of Edinburgh Division of Pathology, Edinburgh Cancer Research Centre, Institute of Genetics & Molecular Medicine, Western General Hospital, Edinburgh, EH4 2XR, United Kingdom;
  • Bosenberg MW; Department of Dermatology, Yale University, New Haven, CT 06520;
  • Bollag G; Plexxikon Inc., Berkeley, CA 94710; and.
  • Tuveson DA; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, United Kingdom; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724 dtuveson@cshl.edu da1@sanger.ac.uk.
  • Adams DJ; Experimental Cancer Genetics and dtuveson@cshl.edu da1@sanger.ac.uk.
Proc Natl Acad Sci U S A ; 112(6): E536-45, 2015 Feb 10.
Article em En | MEDLINE | ID: mdl-25624498
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteína Oncogênica p21(ras) / Resistencia a Medicamentos Antineoplásicos / Proteínas Proto-Oncogênicas B-raf / Proteínas Proto-Oncogênicas c-akt / Melanoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteína Oncogênica p21(ras) / Resistencia a Medicamentos Antineoplásicos / Proteínas Proto-Oncogênicas B-raf / Proteínas Proto-Oncogênicas c-akt / Melanoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article