Targeting cannabinoid receptor-2 pathway by phenylacetylamide suppresses the proliferation of human myeloma cells through mitotic dysregulation and cytoskeleton disruption.

Feng, Rentian; Tong, Qin; Xie, Zhaojun; Cheng, Haizi; Wang, Lirong; Lentzsch, Suzanne; Roodman, G David; Xie, Xiang-Qun

Feng, Rentian; Tong, Qin; Xie, Zhaojun; Cheng, Haizi; Wang, Lirong; Lentzsch, Suzanne; Roodman, G David; Xie, Xiang-Qun.

Afiliação

Feng R; Department of Pharmaceutical Sciences and Drug Discovery Institute, Computational Chemical Genomics Screening Center, School of Pharmacy, and NIH NIDA Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania.
Tong Q; Department of Pharmaceutical Sciences and Drug Discovery Institute, Computational Chemical Genomics Screening Center, School of Pharmacy, and NIH NIDA Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania.
Xie Z; Department of Pharmaceutical Sciences and Drug Discovery Institute, Computational Chemical Genomics Screening Center, School of Pharmacy, and NIH NIDA Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania.
Cheng H; Department of Pharmaceutical Sciences and Drug Discovery Institute, Computational Chemical Genomics Screening Center, School of Pharmacy, and NIH NIDA Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania.
Wang L; Department of Pharmaceutical Sciences and Drug Discovery Institute, Computational Chemical Genomics Screening Center, School of Pharmacy, and NIH NIDA Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, Pennsylvania.
Lentzsch S; Department of Computational Biology, Joint Pitt/CMU Computational Biology Program, University of Pittsburgh, Pittsburgh, Pennsylvania.
Roodman GD; Division of Hematology/Oncology, Columbia University, New York.
Xie XQ; Hematology/Oncology, Department of Medicine, Indiana University, Indianapolis, Indiana.

Mol Carcinog ; 54(12): 1796-806, 2015 Dec.

Article em En | MEDLINE | ID: mdl-25640641

Assuntos

Agonistas de Receptores de Canabinoides/farmacologia; Proliferação de Células/efeitos dos fármacos; Citoesqueleto/efeitos dos fármacos; Mitose/efeitos dos fármacos; Mieloma Múltiplo/tratamento farmacológico; Mieloma Múltiplo/genética; Receptor CB2 de Canabinoide/genética; Actinas/genética; Apoptose/efeitos dos fármacos; Apoptose/genética; Proteína Quinase CDC2/genética; Caspases/genética; Proteínas de Ciclo Celular/genética; Linhagem Celular Transformada; Proliferação de Células/genética; Citoesqueleto/genética; Inativação Gênica/efeitos dos fármacos; Humanos; Mitose/genética; Receptor CB2 de Canabinoide/agonistas; Receptores do Ligante Indutor de Apoptose Relacionado a TNF/genética; Sindecana-1/genética; Tubulina (Proteína)/genética; Regulação para Cima/efeitos dos fármacos; Regulação para Cima/genética

Palavras-chave

apoptosis; cannabinoid receptor-2; cell cycle; cytoskeleton; multiple myeloma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Citoesqueleto / Receptor CB2 de Canabinoide / Proliferação de Células / Agonistas de Receptores de Canabinoides / Mitose / Mieloma Múltiplo Limite: Humans Idioma: En Revista: Mol Carcinog Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article

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