Expression of functional postjunctional alpha 2-adrenoceptors in rabbit isolated distal saphenous artery--a permissive role for angiotensin II?
Br J Pharmacol
; 96(2): 259-61, 1989 Feb.
Article
em En
| MEDLINE
| ID: mdl-2564291
ABSTRACT
In the rabbit isolated distal saphenous artery, the population of postjunctional adrenoceptors is of the alpha 1 variety under normal in vitro experimental conditions, based on the potency order of selective agonists and on the effects of the antagonists prazosin and rauwolscine against responses to UK-14304. Angiotensin II (A II, 0.05 microM) however, without affecting resting baseline tension, markedly enhanced responses to UK-14304, particularly at low concentrations. This previously unseen component of the response to UK-14304 was resistant to prazosin (0.1 microM) but susceptible to rauwolscine (1 microM). A II would therefore appear to have a permissive role for the expression of a quiescent population of postjunctional alpha 2-adrenoceptors in the rabbit distal saphenous artery.
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Coleções:
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Base de dados:
MEDLINE
Assunto principal:
Quinoxalinas
/
Vasoconstrição
/
Angiotensina II
/
Receptores Adrenérgicos alfa
/
Agonistas alfa-Adrenérgicos
Limite:
Animals
Idioma:
En
Revista:
Br J Pharmacol
Ano de publicação:
1989
Tipo de documento:
Article