Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16.

Chalabi-Dchar, Mounira; Cassant-Sourdy, Stéphanie; Duluc, Camille; Fanjul, Marjorie; Lulka, Hubert; Samain, Rémi; Roche, Catherine; Breibach, Florence; Delisle, Marie-Bernadette; Poupot, Mary; Dufresne, Marlène; Shimaoka, Takeshi; Yonehara, Shin; Mathonnet, Muriel; Pyronnet, Stéphane; Bousquet, Corinne

Chalabi-Dchar, Mounira; Cassant-Sourdy, Stéphanie; Duluc, Camille; Fanjul, Marjorie; Lulka, Hubert; Samain, Rémi; Roche, Catherine; Breibach, Florence; Delisle, Marie-Bernadette; Poupot, Mary; Dufresne, Marlène; Shimaoka, Takeshi; Yonehara, Shin; Mathonnet, Muriel; Pyronnet, Stéphane; Bousquet, Corinne.

Afiliação

Chalabi-Dchar M; INSERM UMR-1037, Toulouse University, Cancer Research Center of Toulouse, Equipe Labellisée Ligue Contre le Cancer and Laboratoire d'Excellence Toulouse Cancer, Toulouse, France.
Cassant-Sourdy S; INSERM UMR-1037, Toulouse University, Cancer Research Center of Toulouse, Equipe Labellisée Ligue Contre le Cancer and Laboratoire d'Excellence Toulouse Cancer, Toulouse, France.
Duluc C; INSERM UMR-1037, Toulouse University, Cancer Research Center of Toulouse, Equipe Labellisée Ligue Contre le Cancer and Laboratoire d'Excellence Toulouse Cancer, Toulouse, France.
Fanjul M; INSERM UMR-1037, Toulouse University, Cancer Research Center of Toulouse, Equipe Labellisée Ligue Contre le Cancer and Laboratoire d'Excellence Toulouse Cancer, Toulouse, France.
Lulka H; INSERM UMR-1037, Toulouse University, Cancer Research Center of Toulouse, Equipe Labellisée Ligue Contre le Cancer and Laboratoire d'Excellence Toulouse Cancer, Toulouse, France.
Samain R; INSERM UMR-1037, Toulouse University, Cancer Research Center of Toulouse, Equipe Labellisée Ligue Contre le Cancer and Laboratoire d'Excellence Toulouse Cancer, Toulouse, France.
Roche C; UMR7286 CNRS-Aix-Marseille University, Neurobiology and Neurophysiology Research Center of Marseille, and Laboratory of Molecular Biology, AP-HM Conception, Marseille, France.
Breibach F; Pathology Department, Toulouse Hospitals, Toulouse, France.
Delisle MB; Pathology Department, Toulouse Hospitals, Toulouse, France.
Poupot M; INSERM UMR-1037, Toulouse University, Cancer Research Center of Toulouse, Equipe Labellisée Ligue Contre le Cancer and Laboratoire d'Excellence Toulouse Cancer, Toulouse, France.
Dufresne M; INSERM UMR-1037, Toulouse University, Cancer Research Center of Toulouse, Equipe Labellisée Ligue Contre le Cancer and Laboratoire d'Excellence Toulouse Cancer, Toulouse, France.
Shimaoka T; Department of Molecular Preventive Medicine, Graduate School of Medicine, Tokyo University, Tokyo, Japan.
Yonehara S; Laboratory of Molecular and Cellular Biology, Graduate School of Biostudies, Kyoto University, Kyoto, Japan.
Mathonnet M; EA 3842 Laboratory, Medicine and Pharmacy Faculties, Limoges University, Limoges, France.
Pyronnet S; INSERM UMR-1037, Toulouse University, Cancer Research Center of Toulouse, Equipe Labellisée Ligue Contre le Cancer and Laboratoire d'Excellence Toulouse Cancer, Toulouse, France.
Bousquet C; INSERM UMR-1037, Toulouse University, Cancer Research Center of Toulouse, Equipe Labellisée Ligue Contre le Cancer and Laboratoire d'Excellence Toulouse Cancer, Toulouse, France. Electronic address: corinne.bousquet@inserm.fr.

Gastroenterology ; 148(7): 1452-65, 2015 Jun.

Article em En | MEDLINE | ID: mdl-25683115

Assuntos

Carcinoma Ductal Pancreático/enzimologia; Proliferação de Células; Quimiocina CXCL6/metabolismo; Mutação; Neoplasias Pancreáticas/enzimologia; Fosfatidilinositol 3-Quinase/metabolismo; Proteínas Proto-Oncogênicas p21(ras)/genética; Receptores de Somatostatina/deficiência; Transdução de Sinais; Animais; Carcinoma Ductal Pancreático/genética; Carcinoma Ductal Pancreático/imunologia; Carcinoma Ductal Pancreático/secundário; Estudos de Casos e Controles; Linhagem Celular Tumoral; Quimiocina CXCL16; Quimiocinas CXC/metabolismo; Modelos Animais de Doenças; Predisposição Genética para Doença; Humanos; Metástase Linfática; Camundongos da Linhagem 129; Camundongos Endogâmicos C57BL; Camundongos Knockout; NF-kappa B/metabolismo; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/imunologia; Neoplasias Pancreáticas/patologia; Fenótipo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Receptores Depuradores/metabolismo; Receptores de Somatostatina/genética; Receptores de Somatostatina/metabolismo; Fatores de Tempo; Transfecção; Carga Tumoral; Regulação para Cima

Palavras-chave

Mouse Model; Oncogene; Signal Transduction; Tumor Suppressor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Transdução de Sinais / Proteínas Proto-Oncogênicas p21(ras) / Receptores de Somatostatina / Carcinoma Ductal Pancreático / Proliferação de Células / Quimiocina CXCL6 / Fosfatidilinositol 3-Quinase / Mutação Tipo de estudo: Observational_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Gastroenterology Ano de publicação: 2015 Tipo de documento: Article País de afiliação: França

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