Light-enabled synthesis of anhydrides and amides.
J Org Chem
; 80(5): 2874-8, 2015 Mar 06.
Article
em En
| MEDLINE
| ID: mdl-25689228
ABSTRACT
Recently, we have demonstrated that the photogeneration of Vilsmeier-Haack reagents is possible using only dimethylformamide (DMF) and tetrabromomethane (CBr4) in the bromination of alcohols. Extending these findings to carboxylic acid substrates has produced a mild and facile approach to the in situ formation of symmetric anhydrides, which were conveniently converted to amide derivatives in a one-pot process. The efficient protocols discussed herein are marked by use of UVA LEDs (365 nm), which have reduced the reaction times and come with a low setup cost.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácidos Carboxílicos
/
Dimetilformamida
/
Álcoois
/
Amidas
/
Hidrocarbonetos Bromados
/
Anidridos
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Canadá