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Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum.
McLean, Kirsty J; Hans, Marcus; Meijrink, Ben; van Scheppingen, Wibo B; Vollebregt, Aad; Tee, Kang Lan; van der Laan, Jan-Metske; Leys, David; Munro, Andrew W; van den Berg, Marco A.
Afiliação
  • McLean KJ; Manchester Institute of Biotechnology, Faculty of Life Sciences, The University of Manchester, Manchester M1 7DN, United Kingdom; and.
  • Hans M; DSM Biotechnology Center, 2613 AX, Delft, The Netherlands.
  • Meijrink B; DSM Biotechnology Center, 2613 AX, Delft, The Netherlands.
  • van Scheppingen WB; DSM Biotechnology Center, 2613 AX, Delft, The Netherlands.
  • Vollebregt A; DSM Biotechnology Center, 2613 AX, Delft, The Netherlands.
  • Tee KL; Manchester Institute of Biotechnology, Faculty of Life Sciences, The University of Manchester, Manchester M1 7DN, United Kingdom; and.
  • van der Laan JM; DSM Biotechnology Center, 2613 AX, Delft, The Netherlands.
  • Leys D; Manchester Institute of Biotechnology, Faculty of Life Sciences, The University of Manchester, Manchester M1 7DN, United Kingdom; and.
  • Munro AW; Manchester Institute of Biotechnology, Faculty of Life Sciences, The University of Manchester, Manchester M1 7DN, United Kingdom; and andrew.munro@manchester.ac.uk marco.berg-van-den@dsm.com.
  • van den Berg MA; DSM Biotechnology Center, 2613 AX, Delft, The Netherlands andrew.munro@manchester.ac.uk marco.berg-van-den@dsm.com.
Proc Natl Acad Sci U S A ; 112(9): 2847-52, 2015 Mar 03.
Article em En | MEDLINE | ID: mdl-25691737
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium chrysogenum / Proteínas Fúngicas / Pravastatina / Sistema Enzimático do Citocromo P-450 Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Penicillium chrysogenum / Proteínas Fúngicas / Pravastatina / Sistema Enzimático do Citocromo P-450 Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2015 Tipo de documento: Article