RFLP-defined HLA-DP polymorphism in four ethnic groups.
Hum Immunol
; 25(3): 169-79, 1989 Jul.
Article
em En
| MEDLINE
| ID: mdl-2570050
ABSTRACT
Patterns of BglII, MspI, and TaqI DP alpha and DP beta hybridizing restriction fragment length polymorphisms are compared with primed lymphocyte typing--determined specificities in 28 10th International Histocompatibility Workshop core cell lines. Correlation of specific RFLP patterns with most recognized DP types is confirmed, although the RFLPs do not distinguish DPw3 from DPw6. Analysis of DP-region nucleotide sequence data shows that the observed RFLPs are those expected to hybridize to the DP alpha and beta probes and are thus not due to cross-hybridization to other genes. The distribution of RFLPs in Chinese, Micronesian, South Indian, and white Australian populations is described. The most frequent DP specificity in Chinese is DPw5. In the other populations DPw4 is the most common specificity, although DPw5 is also relatively common in Micronesians. Four new DP alpha RFLP patterns and three new DP beta patterns are described. There are also numerous unusual combinations of DP alpha and DP beta alleles particularly in the South Indian population.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Polimorfismo de Fragmento de Restrição
/
Etnicidade
/
Antígenos HLA-DP
Limite:
Humans
País/Região como assunto:
Asia
/
Oceania
Idioma:
En
Revista:
Hum Immunol
Ano de publicação:
1989
Tipo de documento:
Article