[Principles of biological aging]. / Grundlagen der biologischen Alterung.
Z Gerontol Geriatr
; 48(3): 285-94, 2015 Apr.
Article
em De
| MEDLINE
| ID: mdl-25700994
ABSTRACT
The aging process is the substrate on which aging-associated diseases develop; therefore, the scientific discipline of gerontology aims at understanding this biological aging process, which refers to the progressive increase in the risk of death caused by a loss of body functions. Studies in simple model organisms demonstrate that pharmacological substances, genetic interventions and dietary restriction can slow down the process of aging. The cell culture model of cellular senescence gives researchers the opportunity to conduct studies in a system more closely related to the human organism; therefore, cells from different human tissues are cultured in vitro until they stop proliferating. This permanent growth arrest is called cellular senescence. Recent studies have demonstrated that senescent cells also accumulate in many tissues in vivo and contribute to age-related pathologies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Senescência Celular
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Dieta
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Comportamento Alimentar
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Modelos Biológicos
Limite:
Female
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Humans
/
Male
Idioma:
De
Revista:
Z Gerontol Geriatr
Assunto da revista:
GERIATRIA
Ano de publicação:
2015
Tipo de documento:
Article