[Diagnostic role of galectin-3]. / Galektyna-3 w diagnostyce laboratoryjnej.
Pol Merkur Lekarski
; 37(222): 348-52, 2014 Dec.
Article
em Pl
| MEDLINE
| ID: mdl-25715576
ABSTRACT
The meaning of galectin-3 role in the diagnostics of different diseases was disscused in the paper. Galectin-3 is endogenous, soluble beta- galactoside-binding lectin, which occur in the cell nucleus, the cytoplasm and on the surface of certain cells. Galectin-3 controls cell cycle, modulates adhesion, affects the mRNA splicing, extracellular matrix interactions and cellular differentiation. Galectin-3, also affects to procollagen I which irreversibly crosslinks to form collagen and results in parenchymal organs fibrosis. Taking into account numerous research and knowledge of action mechanism of galectin-3 there were presented changes in its activity in the pathological processes of the human body, including heart failure, liver fibrosis and tumors. The results of published clinical studies have shown its high diagnostic sensitivity, which probably enables to application in laboratory diagnosis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biomarcadores Tumorais
/
Galectina 3
/
Cardiopatias
/
Cirrose Hepática
/
Pneumopatias
/
Neoplasias
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Pl
Revista:
Pol Merkur Lekarski
Assunto da revista:
MEDICINA
Ano de publicação:
2014
Tipo de documento:
Article