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A coumarin lignanoid from the stems of Kadsura heteroclita.
Su, Wei; Zhao, Jianping; Yang, Min; Yan, Hui-Wen; Pang, Tao; Chen, Sheng-Huang; Huang, Hui-Yong; Zhang, Shui-Han; Ma, Xiao-Chi; Guo, De-An; Khan, Ikhlas A; Wang, Wei.
Afiliação
  • Su W; TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
  • Zhao J; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS 38677, USA.
  • Yang M; Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, CAS, Shanghai 201203, China.
  • Yan HW; School of Life Sciences, Central South University, Changsha 410013, China.
  • Pang T; State Key Laboratory of Natural Medicines, New Drug Screening Center, China Pharmaceutical University, Nanjing 210009, China.
  • Chen SH; TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
  • Huang HY; TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
  • Zhang SH; TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
  • Ma XC; College of Pharmacy, Dalian Medical University, Dalian 116044, China.
  • Guo DA; Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology, Shanghai Institute of Materia Medica, CAS, Shanghai 201203, China.
  • Khan IA; National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, MS 38677, USA.
  • Wang W; TCM and Ethnomedicine Innovation & Development Laboratory, Sino-Luxemburg TCM Research Center, School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China. Electronic address: wangwei402@hotmail.com.
Bioorg Med Chem Lett ; 25(7): 1506-8, 2015 Apr 01.
Article em En | MEDLINE | ID: mdl-25736995
ABSTRACT
Coumarinlignan (1), possessing a unique coumarin-containing lignan skeleton, was isolated from the stems of Kadsura heteroclita. Its structure and absolute configuration were determined by spectroscopic techniques, especially 2D NMR and X-ray crystallographic data analyses. The proposed biosynthetic pathway is discussed. This new compound showed good anti-HBV activity against HBeAg and HBsAg, and moderate anti-fibrotic and neuroprotective activities.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Vírus da Hepatite B / Lignanas / Caules de Planta / Fármacos Neuroprotetores / Cumarínicos / Kadsura Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Vírus da Hepatite B / Lignanas / Caules de Planta / Fármacos Neuroprotetores / Cumarínicos / Kadsura Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China