Growth inhibition and induction of phenotypic alterations by L-histidinol in B16 mouse melanoma cells.
Cancer Lett
; 47(3): 193-7, 1989 Oct.
Article
em En
| MEDLINE
| ID: mdl-2576843
ABSTRACT
L-Histidinol, a histidine analog was recently shown to be an inducer of differentiation in the promyelocytic cell line HL-60. In the present study we show that L-histidinol inhibits the growth of B16 melanoma cells in vitro. Growth inhibition is accompanied by phenotypic alterations that include a marked increase in the activities of NADPH cytochrome c reductase and gamma glutamyl transpeptidase, lipid accumulation and cell enlargement. These phenotypic alterations are similar to those induced by other chemical inducers of differentiation in melanoma cells.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Divisão Celular
/
Histidinol
/
Imidazóis
/
Melanoma
Limite:
Animals
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Israel