Ionic current inversion in pressure-driven polymer translocation through nanopores.
Phys Rev Lett
; 114(8): 088303, 2015 Feb 27.
Article
em En
| MEDLINE
| ID: mdl-25768784
ABSTRACT
We predict streaming current inversion with multivalent counterions in hydrodynamically driven polymer translocation events from a correlation-corrected charge transport theory including charge fluctuations around mean-field electrostatics. In the presence of multivalent counterions, electrostatic many-body effects result in the reversal of the DNA charge. The attraction of anions to the charge-inverted DNA molecule reverses the sign of the ionic current through the pore. Our theory allows for a comprehensive understanding of the complex features of the resulting streaming currents. The underlying mechanism is an efficient way to detect DNA charge reversal in pressure-driven translocation experiments with multivalent cations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
/
Nanoporos
/
Modelos Químicos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Phys Rev Lett
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Turquia