Macrophages and iron trafficking at the birth and death of red cells.
Blood
; 125(19): 2893-7, 2015 May 07.
Article
em En
| MEDLINE
| ID: mdl-25778532
ABSTRACT
Macrophages play a critical role in iron homeostasis via their intimate association with developing and dying red cells. Central nurse macrophages promote erythropoiesis in the erythroblastic island niche. These macrophages make physical contact with erythroblasts, enabling signaling and the transfer of growth factors and possibly nutrients to the cells in their care. Human mature red cells have a lifespan of 120 days before they become senescent and again come into contact with macrophages. Phagocytosis of red blood cells is the main source of iron flux in the body, because heme must be recycled from approximately 270 billion hemoglobin molecules in each red cell, and roughly 2 million senescent red cells are recycled each second. Here we will review pathways for iron trafficking found at the macrophage-erythroid axis, with a focus on possible roles for the transport of heme in toto.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Eritrócitos
/
Ferro
/
Macrófagos
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Blood
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Moldávia