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17-Norpimaranes and (9ßH)-17-Norpimaranes from the Tuber of Icacina trichantha.
Zhao, Ming; Onakpa, Michael Monday; Chen, Wei-Lun; Santarsiero, Bernard D; Swanson, Steven M; Burdette, Joanna E; Asuzu, Isaac Uzoma; Che, Chun-Tao.
Afiliação
  • Zhao M; †Department of Medicinal Chemistry and Pharmacognosy and WHO Collaborating Center for Traditional Medicine, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
  • Onakpa MM; †Department of Medicinal Chemistry and Pharmacognosy and WHO Collaborating Center for Traditional Medicine, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
  • Chen WL; ‡Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria.
  • Santarsiero BD; †Department of Medicinal Chemistry and Pharmacognosy and WHO Collaborating Center for Traditional Medicine, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
  • Swanson SM; §Center for Pharmaceutical Biotechnology and Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois 60607, United States.
  • Burdette JE; †Department of Medicinal Chemistry and Pharmacognosy and WHO Collaborating Center for Traditional Medicine, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
  • Asuzu IU; ⊥School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
  • Che CT; †Department of Medicinal Chemistry and Pharmacognosy and WHO Collaborating Center for Traditional Medicine, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
J Nat Prod ; 78(4): 789-96, 2015 Apr 24.
Article em En | MEDLINE | ID: mdl-25782063
ABSTRACT
Seven new 17-norpimarane and (9ßH)-17-norpimarane diterpenoids, icacinlactones A-G (1-7), were isolated from the tuber of Icacina trichantha. The structures were elucidated by spectroscopic and HRMS techniques, and the absolute configuration of 2 was determined by means of X-ray crystallographic analysis. Compounds 1-7, as well as four known related structures, were evaluated for cytotoxic activity against MDA-MB-435 (human melanoma cancer), MDA-MB-231 (human breast cancer), and OVCAR3 (human ovarian cancer) cell lines. Several of these natural products displayed significant cytotoxic activity, with humirianthenolide C being the most active.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Magnoliopsida / Abietanos / Antineoplásicos Fitogênicos Limite: Female / Humans País/Região como assunto: Africa Idioma: En Revista: J Nat Prod Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Magnoliopsida / Abietanos / Antineoplásicos Fitogênicos Limite: Female / Humans País/Região como assunto: Africa Idioma: En Revista: J Nat Prod Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos