Adenovirus membrane penetration: Tickling the tail of a sleeping dragon.
Virology
; 479-480: 591-9, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25798531
ABSTRACT
As is the case for nearly every viral pathogen, non-enveloped viruses (NEV) must maintain their integrity under potentially harsh environmental conditions while retaining the ability to undergo rapid disassembly at the right time and right place inside host cells. NEVs generally exist in this metastable state until they encounter key cellular stimuli such as membrane receptors, decreased intracellular pH, digestion by cellular proteases, or a combination of these factors. These stimuli trigger conformational changes in the viral capsid that exposes a sequestered membrane-perturbing protein. This protein subsequently modifies the cell membrane in such a way as to allow passage of the virion and accompanying nucleic acid payload into the cell cytoplasm. Different NEVs employ variations of this general pathway for cell entry (Moyer and Nemerow, 2011, Curr. Opin. Virol., 1, 44-49), however this review will focus on significant new knowledge obtained on cell entry by human adenovirus (HAdV).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Virais
/
Membrana Celular
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Adenoviridae
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Internalização do Vírus
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Interações Hospedeiro-Patógeno
Limite:
Animals
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Humans
Idioma:
En
Revista:
Virology
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos