The ultrastructural localization of enkephalin and substance P immunoreactivities in the nucleus tractus solitarii of the cat.
J Comp Neurol
; 233(4): 490-6, 1985 Mar 22.
Article
em En
| MEDLINE
| ID: mdl-2579982
ABSTRACT
In the medial and commissural subdivisions of the nucleus tractus solitarii enkephalin and substance P immunoreactivities were localized within synaptic terminals, unmyelinated axons, and neuronal cell bodies. Both enkephalin and substance P immunoreactivities were contained within synaptic terminals which had a mixture of small clear vesicles and dense core vesicles. The presence of dense core vesicles within both the enkephalin- and substance P-immunoreactive terminals was a consistent feature, although they were not associated with the actual synaptic junction. While enkephalin- and substance P-immunoreactive terminals shared a similar morphology, their respective distributions along the dendritic tree were quite distinct. Enkephalin-immunoreactive terminals contacted mainly the cell body and proximal portions of the dendritic tree. In contrast, substance P-immunoreactive terminals synapsed predominantly with spines and shafts of small to medium-sized dendrites. Few substance P-immunoreactive terminals contacted proximal dendrites and they were never presynaptic to the neuronal cell body. This apparent segregation of synaptic terminals on neurons suggests that enkephalin synapses have a more pronounced effect than substance P terminals.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encefalinas
/
Bulbo
/
Substância P
Limite:
Animals
Idioma:
En
Revista:
J Comp Neurol
Ano de publicação:
1985
Tipo de documento:
Article