Fibroblast growth factor signaling in the vasculature.
Curr Atheroscler Rep
; 17(6): 509, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25813213
ABSTRACT
Despite their discovery as angiogenic factors and mitogens for endothelial cells more than 30 years ago, much remains to be determined about the role of fibroblast growth factors (FGFs) and their receptors in vascular development, homeostasis, and disease. In vitro studies show that members of the FGF family stimulate growth, migration, and sprouting of endothelial cells, and growth, migration, and phenotypic plasticity of vascular smooth muscle cells. Recent studies have revealed important roles for FGFs and their receptors in the regulation of endothelial cell sprouting and vascular homeostasis in vivo. Furthermore, recent work has revealed roles for FGFs in atherosclerosis, vascular calcification, and vascular dysfunction. The large number of FGFs and their receptors expressed in endothelial and vascular smooth muscle cells complicates these studies. In this review, we summarize recent studies in which new and unanticipated roles for FGFs and their receptors in the vasculature have been revealed.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
/
Miócitos de Músculo Liso
/
Células Endoteliais
/
Fatores de Crescimento de Fibroblastos
/
Músculo Liso Vascular
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Atheroscler Rep
Assunto da revista:
ANGIOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos