Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.

Hoang, Huy N; Song, Kun; Hill, Timothy A; Derksen, David R; Edmonds, David J; Kok, W Mei; Limberakis, Chris; Liras, Spiros; Loria, Paula M; Mascitti, Vincent; Mathiowetz, Alan M; Mitchell, Justin M; Piotrowski, David W; Price, David A; Stanton, Robert V; Suen, Jacky Y; Withka, Jane M; Griffith, David A; Fairlie, David P

Hoang, Huy N; Song, Kun; Hill, Timothy A; Derksen, David R; Edmonds, David J; Kok, W Mei; Limberakis, Chris; Liras, Spiros; Loria, Paula M; Mascitti, Vincent; Mathiowetz, Alan M; Mitchell, Justin M; Piotrowski, David W; Price, David A; Stanton, Robert V; Suen, Jacky Y; Withka, Jane M; Griffith, David A; Fairlie, David P.

Afiliação

Hoang HN; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
Hill TA; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
Kok WM; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
Mitchell JM; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
Suen JY; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.
Fairlie DP; Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

J Med Chem ; 58(9): 4080-5, 2015 May 14.

Article em En | MEDLINE | ID: mdl-25839426

Assuntos

Peptídeos Cíclicos/química; Receptores de Glucagon/agonistas; Animais; Células CHO; Dicroísmo Circular; Cricetulus; AMP Cíclico/biossíntese; Receptor do Peptídeo Semelhante ao Glucagon 1; Humanos; Interações Hidrofóbicas e Hidrofílicas; Modelos Moleculares; Ressonância Magnética Nuclear Biomolecular; Peptídeos Cíclicos/farmacologia; Estrutura Secundária de Proteína; Ensaio Radioligante; Relação Estrutura-Atividade

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Receptores de Glucagon Limite: Animals / Humans Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Austrália

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