Sarcomere Disruptions of Slow Fiber Resulting From Mountain Ultramarathon.
Int J Sports Physiol Perform
; 10(8): 1041-7, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-25848839
ABSTRACT
OBJECTIVE:
To investigate changes after a mountain ultramarathon (MUM) in the serum concentration of fast (FM) and slow (SM) myosin isoforms, which are fiber-type-specific sarcomere proteins. The changes were compared against creatine kinase (CK), a widely used fiber-sarcolemma-damage biomarker, and cardiac troponin I (cTnI), a widely used cardiac biomarker.METHODS:
Observational comparison of response in a single group of 8 endurance-trained amateur athletes. Time-related changes in serum levels of CK, cTnI, SM, and FM from competitors were analyzed before, 1 h after the MUM, and 24 and 48 h after the start of the MUM by 1-way ANOVA for repeated measures or Friedman and Wilcoxon tests. Pearson correlation coefficient was employed to examine associations between variables.RESULTS:
While SM was significantly (P = .009) increased in serum 24 h after the beginning of the MUM, FM and cTnI did not change significantly. Serum CK activity peak was observed 1 h after the MUM (P = .002). Moreover, serum peaks of CK and SM were highly correlated (r = .884, P = .004).CONCLUSIONS:
Since there is evidence of muscle damage after prolonged mountain running, the increase in SM serum concentration after a MUM could be indirect evidence of slow- (type I) fiber-specific sarcomere disruptions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Resistência Física
/
Corrida
/
Sarcômeros
/
Músculo Esquelético
/
Fibras Musculares de Contração Lenta
/
Miosina Tipo I
/
Miosinas de Músculo Esquelético
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Int J Sports Physiol Perform
Assunto da revista:
FISIOLOGIA
/
MEDICINA ESPORTIVA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Espanha