Constituents of the aerial parts of Eclipta prostrata and their cytotoxicity on human ovarian cancer cells in vitro.

ABSTRACT

A new terthiophene, 3'-hydroxy-2,2'5',2″-terthiophene-3'-O-ß-D-glucopyranoside (1) and a new oleanane-type saponin, echinocystic acid-3-O-(6-O-acetyl)-ß-D-glucopyranoside (7) were isolated from the aerial parts of Eclipta prostrata L. Moreover, five thiophenes (2-6), seven triterpenoids (8-14), two coumestans (15 and 16), and four flavonoids (17-20) having previously known chemical structures were isolated during the same course of this study. All the isolates 1-20 were evaluated for their cytotoxicity against human ovarian cancer cells (SKOV3) using MTT assays.