New insights into the mechanism of DNA mismatch repair.
Chromosoma
; 124(4): 443-62, 2015 Dec.
Article
em En
| MEDLINE
| ID: mdl-25862369
ABSTRACT
The genome of all organisms is constantly being challenged by endogenous and exogenous sources of DNA damage. Errors like basebase mismatches or small insertions and deletions, primarily introduced by DNA polymerases during DNA replication are repaired by an evolutionary conserved DNA mismatch repair (MMR) system. The MMR system, together with the DNA replication machinery, promote repair by an excision and resynthesis mechanism during or after DNA replication, increasing replication fidelity by up-to-three orders of magnitude. Consequently, inactivation of MMR genes results in elevated mutation rates that can lead to increased cancer susceptibility in humans. In this review, we summarize our current understanding of MMR with a focus on the different MMR protein complexes, their function and structure. We also discuss how recent findings have provided new insights in the spatio-temporal regulation and mechanism of MMR.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Reparo de Erro de Pareamento de DNA
Limite:
Humans
Idioma:
En
Revista:
Chromosoma
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Alemanha