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Whole-liver diffusion-weighted MRI histogram analysis: effect of the presence of colorectal hepatic metastases on the remaining liver parenchyma.
Lambregts, Doenja M J; Martens, Milou H; Quah, Raymond C W; Nikiforaki, Katerina; Heijnen, Luc A; Dejong, Cornelis H C; Beets, Geerard L; Marias, Kostas; Papanikolaou, Nickolas; Beets-Tan, Regina G H.
Afiliação
  • Lambregts DM; Departments of aRadiology bSurgery, Maastricht University Medical Center cGROW School for Oncology and Developmental Biology, Maastricht, The Netherlands dDepartment of Radiology, Alexandra Hospital, Jurong Health, Singapore, Singapore eLaboratory of Computational Medicine, Institute of Computer Science, FORTH, Heraklion, Crete, Greece.
Eur J Gastroenterol Hepatol ; 27(4): 399-404, 2015 Apr.
Article em En | MEDLINE | ID: mdl-25874512
OBJECTIVES: To explore whether whole-liver diffusion-weighted MRI analysis (of the apparently normal liver parenchyma) can help differentiate between patients with colorectal liver metastasis and controls without liver disease. MATERIALS AND METHODS: Ten patients with colorectal liver metastasis and 10 controls with no focal/diffuse liver disease underwent liver MRI at 1.5 T including diffusion-weighted imaging (DWI; b-values 0, 50, 100, 500, 750, 1000). Apparent diffusion coefficient (ADC) maps were calculated from the DWI images to carry out quantitative diffusion analyses. An experienced reader performed segmentation of the apparently nondiseased liver (excluding metastases/focal liver lesions) on the ADC maps. Histogram ADC parameters were calculated and compared between the patients and the controls. RESULTS: The mean liver ADC was 0.95×10⁻³ mm²/s for the patients versus 1.03×10⁻³ mm²/s for the controls (P=0.42). The fifth percentile of the ADC was significantly lower for the patients compared with the controls (0.45 vs. 0.69 10⁻³ mm²/s, P=0.01). The SD was significantly higher in the patient group (0.30 vs. 0.22, P<0.001). Median, skewness, kurtosis, and 30th-95th percentile were not significantly different between the two groups. Areas under the receiver operator characteristics curves to differentiate patients with metastatic liver involvement from healthy controls without liver disease were 0.79 for the fifth percentile and 0.95 for the SD. CONCLUSION: Whole-liver diffusion-weighted MRI histogram analysis showed a significant shift towards lower fifth percentile ADC values and higher SD in patients with colorectal liver metastasis compared with controls without liver disease.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interpretação de Imagem Assistida por Computador / Neoplasias Colorretais / Imagem de Difusão por Ressonância Magnética / Fígado / Neoplasias Hepáticas Tipo de estudo: Evaluation_studies / Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Gastroenterol Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Grécia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interpretação de Imagem Assistida por Computador / Neoplasias Colorretais / Imagem de Difusão por Ressonância Magnética / Fígado / Neoplasias Hepáticas Tipo de estudo: Evaluation_studies / Observational_studies / Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Gastroenterol Hepatol Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Grécia