Gamma-irradiated ß-glucan induces immunomodulation and anticancer activity through MAPK and NF-κB pathways.
J Sci Food Agric
; 96(2): 695-702, 2016 Jan 30.
Article
em En
| MEDLINE
| ID: mdl-25880631
ABSTRACT
BACKGROUND:
This study was designed to evaluate the antitumor activity of low-molecular-weight ß-glucan (LMBG) produced by gamma irradiation (50 kGy), using in vivo and in vitro models.RESULTS:
The results indicate that treatment with LMBG increased the proliferation of murine peritoneal macrophages, and their production of tumor necrosis factor α and nitric oxide, to a greater extent than treatment with high-molecular-weight ß-glucan (HMBG). The activation of peritoneal macrophages by LMBG was mediated by both mitogen-activated protein kinases and nuclear factor-κB signaling. Interestingly, when administered prophylactically, LMBG significantly inhibited tumor growth and lung metastasis in mice injected with B16BL6 melanoma cells compared with the HMBG-treated group. In comparison with HMBG treatment, LMBG treatment also elevated cell proliferation, cytokine (interferon-γ and interleukin-2) production, and CD8(+) T cell populations in splenocytes from tumor-bearing mice.CONCLUSION:
These data indicate that LMBG is important in eliciting antitumor activity through a non-specific immune response and may play a major role as a value-added product in the medical industry.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
NF-kappa B
/
Proteínas Quinases Ativadas por Mitógeno
/
Beta-Glucanas
/
Imunomodulação
/
Raios gama
/
Antineoplásicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Sci Food Agric
Ano de publicação:
2016
Tipo de documento:
Article