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Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review.
He, Chun-Lan; Chen, Ping; Xia, Bing-Lan; Xiao, Qin; Cai, Feng-Lin.
Afiliação
  • He CL; Department of Thyroid and Breast Surgery, Subei People's Hospital, Yangzhou University, No. 98 Nantong West Road, Yangzhou, 225001, Jiangsu Province, China. 13951059910@163.com.
  • Chen P; Department of Gastrointestinal Surgery, Subei People's Hospital, Yangzhou University, No. 98 Nantong West Road, Yangzhou, 225001, Jiangsu Province, China. chen86ky@126.com.
  • Xia BL; Department of Ultrasonography, Subei People's Hospital, Yangzhou University, No. 98 Nantong West Road, Yangzhou, 225001, Jiangsu Province, China. 493283707@qq.com.
  • Xiao Q; Department of Pathology, Subei People's Hospital, Yangzhou University, No. 98 Nantong West Road, Yangzhou, 225001, Jiangsu Province, China. lykk678@sina.com.
  • Cai FL; Department of Thyroid and Breast Surgery, Subei People's Hospital, Yangzhou University, No. 98 Nantong West Road, Yangzhou, 225001, Jiangsu Province, China. wanghao_ky@126.com.
World J Surg Oncol ; 13: 120, 2015 Mar 26.
Article em En | MEDLINE | ID: mdl-25890325
BACKGROUND: Cases of primary gastric adenocarcinoma with metastasis to the breast are extremely rare. Till now, only 38 cases have been reported in PubMed since 1908. CASE PRESENTATION: We herein reported a race case of gastric adenocarcinoma with metastasis to the right breast. Breast biopsy showed invasive signet-ring cell breast carcinoma in the right breast. She was given a TEC regimen (docetaxel 75 mg/m(2), epirubicin 75 mg/m(2), and cyclophosphamide 600 mg/m(2) every 3 weeks) for one cycle but showed no objective response. Upper gastrointestinal endoscopy demonstrated an ulcerative mass in the gastric body. Biopsy demonstrated low-grade gastric adenocarcinoma with signet-ring features. In immunohistochemistry, mammary malignant cells were positive for cytokeratin 7, cytokeratin 20, villin, and ErbB2/HER2, but negative for gross cystic disease fluid protein-15, estrogen receptor, and progesterone receptor. The diagnosis of metastatic poorly differentiated signet-ring cell adenocarcinoma of the right breast identical to gastric primary was confirmed finally. CONCLUSIONS: Gastric cancer with metastasis to the breast can be diagnosed by clinical history, histological findings, and immunohistochemical markers.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Neoplasias da Mama / Biomarcadores Tumorais / Carcinoma de Células em Anel de Sinete Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Female / Humans / Middle aged Idioma: En Revista: World J Surg Oncol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Neoplasias da Mama / Biomarcadores Tumorais / Carcinoma de Células em Anel de Sinete Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Female / Humans / Middle aged Idioma: En Revista: World J Surg Oncol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: China