Mutual interdependence of splicing and transcription elongation.
Transcription
; 6(2): 37-9, 2015.
Article
em En
| MEDLINE
| ID: mdl-25890997
ABSTRACT
Transcription and splicing are intrinsically linked, as splicing needs a pre-mRNA substrate to commence. The more nuanced view is that the rate of transcription contributes to splicing regulation. On the other hand there is accumulating evidence that splicing has an active role in controlling transcription elongation by DNA-dependent RNA polymerase II (RNAP II). We briefly review those mechanisms and propose a unifying model where splicing controls transcription elongation to provide an optimal timing for successive rounds of splicing.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
RNA Polimerase II
/
Splicing de RNA
Limite:
Humans
Idioma:
En
Revista:
Transcription
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Polônia