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Pleomorphic Lobular Carcinoma In Situ: Radiologic-Pathologic Features and Clinical Management.
Flanagan, Meghan R; Rendi, Mara H; Calhoun, Kristine E; Anderson, Benjamin O; Javid, Sara H.
Afiliação
  • Flanagan MR; Department of Surgery, University of Washington Medical Center, Seattle, WA, USA.
  • Rendi MH; Department of Anatomic Pathology, University of Washington Medical Center, Seattle, WA, USA.
  • Calhoun KE; Department of Surgery, University of Washington Medical Center, Seattle, WA, USA.
  • Anderson BO; Department of Surgery, University of Washington Medical Center, Seattle, WA, USA.
  • Javid SH; Department of Surgery, University of Washington Medical Center, Seattle, WA, USA. sjavid@uw.edu.
Ann Surg Oncol ; 22(13): 4263-9, 2015 Dec.
Article em En | MEDLINE | ID: mdl-25893410
ABSTRACT

BACKGROUND:

Pleomorphic lobular carcinoma in situ (PLCIS) is an unusual variant of LCIS for which optimal management remains unclear.

METHODS:

We conducted a 15-year (2000-2014) retrospective chart review of the radiologic, pathologic, clinical management, and recurrence rates of patients with PLCIS on diagnostic biopsy. Fifty-one patients were found to have PLCIS either alone or with concomitant breast cancer. Of these, 23 were found to have pure PLCIS on diagnostic biopsy. Rates of upstaging after local excision, positive or close margins, mastectomy, and recurrence associated with pure pleomorphic lobular carcinoma in situ were examined.

RESULTS:

Of the 21 patients who underwent surgical excision following diagnostic biopsy, 33.3 % (7/21) were found to have invasive carcinoma, and 19 % (4/23) were found to have ductal carcinoma in situ. Extensive or multifocal PLCIS was present in 47.6 % (10/21) of patients, corresponding to at least one PLCIS-positive or close margin in 71.4 % (15/21). In total, there were 11 local re-excisions in nine patients, and 12 mastectomies. No ipsilateral breast cancer events have occurred, including in those with positive or close surgical margins (mean follow-up 4.1 years).

CONCLUSIONS:

Patients with isolated PLCIS on diagnostic biopsy are at high risk of upgrading to invasive cancer or ductal carcinoma in situ at diagnostic excision. PLCIS often is extensive, with high rates of positive or close surgical resection margins. If negative PLCIS margins are pursued, rates of successful breast conservation are low. In light of this and low recurrence rates, caution should be exercised in aggressively treating PLCIS with excision to clear margins.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Carcinoma in Situ / Carcinoma Lobular / Carcinoma Intraductal não Infiltrante Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Ann Surg Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Carcinoma in Situ / Carcinoma Lobular / Carcinoma Intraductal não Infiltrante Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Middle aged Idioma: En Revista: Ann Surg Oncol Assunto da revista: NEOPLASIAS Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos