Molecular Regulation of Parturition: The Role of the Decidual Clock.
Cold Spring Harb Perspect Med
; 5(11)2015 Apr 27.
Article
em En
| MEDLINE
| ID: mdl-25918180
ABSTRACT
The timing of birth is a critical determinant of perinatal outcome. Despite intensive research, the molecular mechanisms responsible for the onset of labor both at term and preterm remain unclear. It is likely that a "parturition cascade" exists that triggers labor at term, that preterm labor results from mechanisms that either prematurely stimulate or short-circuit this cascade, and that these mechanisms involve the activation of proinflammatory pathways within the uterus. It has long been postulated that the fetoplacental unit is in control of the timing of birth through a "placental clock." We suggest that it is not a placental clock that regulates the timing of birth, but rather a "decidual clock." Here, we review the evidence in support of the endometrium/decidua as the organ primarily responsible for the timing of birth and discuss the molecular mechanisms that prime this decidual clock.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Relógios Biológicos
/
Decídua
/
Parto
Limite:
Animals
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Female
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Humans
/
Pregnancy
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
Ano de publicação:
2015
Tipo de documento:
Article