[A case of secondary sclerosing cholangitis caused by chemotherapy with nab-paclitaxel].
Nihon Shokakibyo Gakkai Zasshi
; 112(5): 888-95, 2015 May.
Article
em Ja
| MEDLINE
| ID: mdl-25947025
ABSTRACT
A 73-year-old woman had received 9 months of chemotherapy with nab-paclitaxel for locally advanced breast cancer. During the treatment, she was well and showed no major side effects except for alopecia and arthralgia. The tumor showed a tendency to reduction. However, chemotherapy was discontinued because of liver dysfunction. MRCP and ERCP demonstrated multiple stenoses of the hepatic ducts and the intrahepatic bile ducts. We diagnosed chemotherapy-induced sclerosing cholangitis caused by nab-paclitaxel. Treatment with ursodeoxycholic acid and steroid was ineffective. We added bezafibrate, which resulted in a gradual improvement in liver function. To the best of our knowledge, this is the first reported case of nab-paclitaxel-induced secondary sclerosing cholangitis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Colangite Esclerosante
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Paclitaxel
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Albuminas
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Antineoplásicos Fitogênicos
Limite:
Aged
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Female
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Humans
Idioma:
Ja
Revista:
Nihon Shokakibyo Gakkai Zasshi
Ano de publicação:
2015
Tipo de documento:
Article