Mid-regional pro-atrial natriuretic peptide and blood pressure in adolescents: effect of gender and pubertal stage.
Blood Press
; 24(6): 347-52, 2015.
Article
em En
| MEDLINE
| ID: mdl-25968593
ABSTRACT
Little is known about blood pressure in relation to circulating natriuretic peptide concentrations and gender in generally healthy adolescents. We studied 15-year-old females and males (n = 335) from the Danish site of the European Youth Heart Study (EYHS). Blood pressure was measured using a standardized protocol, sexual maturity was assessed according to Tanner stage, and as a surrogate for atrial natriuretic peptide, we measured mid-regional pro-atrial natriuretic peptide (MR-proANP) in plasma. Compared with boys, girls had lower systolic blood pressure (SBP) (mean ± SD 109.6 ± 9.9 mmHg vs 116.9 ± 11.4 mmHg, p < 0.0001) and higher plasma MR-proANP concentrations [median (interquartile range) 42.1 pmol/l (31.9-50.2 pmol/l) vs 36.6 pmol/l (30.6-44.9 pmol/l), p = 0.0046]. When female adolescents were further subdivided according to Tanner stage, there were no differences in blood pressure and plasma MR-proANP concentrations between post-pubertal and pubertal girls (p > 0.17). In contrast, after similar subdivision, post-pubertal boys had higher SBP (mean ± SD 117.7 ± 11.7 mmHg vs 111.4 ± 7.9 mmHg, p = 0.029) and lower plasma MR-proANP concentrations [median (interquartile range) 36.2 pmol/l (30.6-43.1 pmol/l) vs 46.4 pmol/l (30.3-51.1 pmol/l), p = 0.043] compared with pubertal boys. Given their higher SBP, boys had lower than expected plasma concentrations of MR-proANP compared with girls, and given their higher SBP, post-pubertal boys had lower than expected plasma concentrations of MR-proANP compared with pubertal boys.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Puberdade
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Caracteres Sexuais
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Fator Natriurético Atrial
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
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Female
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Humans
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Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Blood Press
Assunto da revista:
ANGIOLOGIA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Dinamarca