Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake Inhibitors.

Hicks, J K; Bishop, J R; Sangkuhl, K; Müller, D J; Ji, Y; Leckband, S G; Leeder, J S; Graham, R L; Chiulli, D L; LLerena, A; Skaar, T C; Scott, S A; Stingl, J C; Klein, T E; Caudle, K E; Gaedigk, A

Hicks, J K; Bishop, J R; Sangkuhl, K; Müller, D J; Ji, Y; Leckband, S G; Leeder, J S; Graham, R L; Chiulli, D L; LLerena, A; Skaar, T C; Scott, S A; Stingl, J C; Klein, T E; Caudle, K E; Gaedigk, A.

Afiliação

Hicks JK; Department of Pharmacy, Cleveland Clinic, Cleveland, Ohio, USA; Genomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA; and Department of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA.
Bishop JR; University of Minnesota College of Pharmacy, Department of Experimental and Clinical Pharmacology, Minneapolis, Minnesota, USA.
Sangkuhl K; Department of Genetics, Stanford University, Stanford, California, USA.
Müller DJ; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
Ji Y; Department of Laboratory Medicine and Pathology, Division of Laboratory Genetics, Mayo Clinic, Rochester, Minnesota, USA.
Leckband SG; Veterans Affairs San Diego Healthcare System, Mental Health Care Line, University of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Psychiatry, San Diego, California, USA.
Leeder JS; Division of Clinical Pharmacology, Toxicology & Innovative Therapeutics, Children's Mercy Hospital, Kansas City, Missouri and Department of Pediatrics, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Graham RL; Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.
Chiulli DL; Veterans Affairs Palo Alto Health Care System, San Jose Division, San Jose, California, USA.
LLerena A; CICAB Clinical Research Center, Extremadura University Hospital and Medical School, Badajoz, Spain.
Skaar TC; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Scott SA; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Stingl JC; Federal Institute of Drugs and Medical Devices, Bonn, Germany.
Klein TE; Department of Genetics, Stanford University, Stanford, California, USA.
Caudle KE; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Gaedigk A; Division of Clinical Pharmacology, Toxicology & Innovative Therapeutics, Children's Mercy Hospital, Kansas City, Missouri and Department of Pediatrics, University of Missouri-Kansas City, Kansas City, Missouri, USA.

Clin Pharmacol Ther ; 98(2): 127-34, 2015 Aug.

Article em En | MEDLINE | ID: mdl-25974703

RESUMO

Selective serotonin reuptake inhibitors (SSRIs) are primary treatment options for major depressive and anxiety disorders. CYP2D6 and CYP2C19 polymorphisms can influence the metabolism of SSRIs, thereby affecting drug efficacy and safety. We summarize evidence from the published literature supporting these associations and provide dosing recommendations for fluvoxamine, paroxetine, citalopram, escitalopram, and sertraline based on CYP2D6 and/or CYP2C19 genotype (updates at www.pharmgkb.org).

Assuntos

Citocromo P-450 CYP2C19/genética; Citocromo P-450 CYP2D6/genética; Cálculos da Dosagem de Medicamento; Farmacogenética/normas; Polimorfismo Genético; Inibidores Seletivos de Recaptação de Serotonina/administração & dosagem; Biotransformação; Citocromo P-450 CYP2C19/metabolismo; Citocromo P-450 CYP2D6/metabolismo; Genótipo; Humanos; Segurança do Paciente; Fenótipo; Medição de Risco; Fatores de Risco; Inibidores Seletivos de Recaptação de Serotonina/efeitos adversos; Inibidores Seletivos de Recaptação de Serotonina/farmacocinética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Farmacogenética / Polimorfismo Genético / Inibidores Seletivos de Recaptação de Serotonina / Citocromo P-450 CYP2D6 / Cálculos da Dosagem de Medicamento / Citocromo P-450 CYP2C19 Tipo de estudo: Etiology_studies / Guideline / Risk_factors_studies Limite: Humans Idioma: En Revista: Clin Pharmacol Ther Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

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