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Prognostic factors and outcomes in primary urethral cancer: results from the international collaboration on primary urethral carcinoma.
Gakis, Georgios; Morgan, Todd M; Efstathiou, Jason A; Keegan, Kirk A; Mischinger, Johannes; Todenhoefer, Tilman; Schubert, Tina; Zaid, Harras B; Hrbacek, Jan; Ali-El-Dein, Bedeir; Clayman, Rebecca H; Galland, Sigolene; Olugbade, Kola; Rink, Michael; Fritsche, Hans-Martin; Burger, Maximilian; Chang, Sam S; Babjuk, Marko; Thalmann, George N; Stenzl, Arnulf; Daneshmand, Siamak.
Afiliação
  • Gakis G; Department of Urology, University of Tübingen, Tübingen, Germany. georgios.gakis@web.de.
  • Morgan TM; Department of Urology, University of Michigan, Ann Arbor, MI, USA.
  • Efstathiou JA; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Keegan KA; Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Mischinger J; Department of Urology, University of Tübingen, Tübingen, Germany.
  • Todenhoefer T; Department of Urology, University of Tübingen, Tübingen, Germany.
  • Schubert T; Department of Urology, University of Tübingen, Tübingen, Germany.
  • Zaid HB; Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Hrbacek J; Department of Urology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Ali-El-Dein B; Mansoura Clinic, Urology and Nephrology Center, Mansoura, Egypt.
  • Clayman RH; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Galland S; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Olugbade K; Department of Urology, University of Michigan, Ann Arbor, MI, USA.
  • Rink M; Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Fritsche HM; Department of Urology, University Hospital Regensburg, Regensburg, Germany.
  • Burger M; Department of Urology, University Hospital Regensburg, Regensburg, Germany.
  • Chang SS; Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Babjuk M; Department of Urology, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Thalmann GN; Department of Urology, University Hospital Berne, Berne, Switzerland.
  • Stenzl A; Department of Urology, University of Tübingen, Tübingen, Germany.
  • Daneshmand S; USC/Norris Comprehensive Cancer Center, Institute of Urology, Los Angeles, CA, USA.
World J Urol ; 34(1): 97-103, 2016 Jan.
Article em En | MEDLINE | ID: mdl-25981402
PURPOSE: To evaluate risk factors for survival in a large international cohort of patients with primary urethral cancer (PUC). METHODS: A series of 154 patients (109 men, 45 women) were diagnosed with PUC in ten referral centers between 1993 and 2012. Kaplan-Meier analysis with log-rank test was used to investigate various potential prognostic factors for recurrence-free (RFS) and overall survival (OS). Multivariate models were constructed to evaluate independent risk factors for recurrence and death. RESULTS: Median age at definitive treatment was 66 years (IQR 58-76). Histology was urothelial carcinoma in 72 (47 %), squamous cell carcinoma in 46 (30 %), adenocarcinoma in 17 (11 %), and mixed and other histology in 11 (7 %) and nine (6 %), respectively. A high degree of concordance between clinical and pathologic nodal staging (cN+/cN0 vs. pN+/pN0; p < 0.001) was noted. For clinical nodal staging, the corresponding sensitivity, specificity, and overall accuracy for predicting pathologic nodal stage were 92.8, 92.3, and 92.4 %, respectively. In multivariable Cox-regression analysis for patients staged cM0 at initial diagnosis, RFS was significantly associated with clinical nodal stage (p < 0.001), tumor location (p < 0.001), and age (p = 0.001), whereas clinical nodal stage was the only independent predictor for OS (p = 0.026). CONCLUSIONS: These data suggest that clinical nodal stage is a critical parameter for outcomes in PUC.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Uretrais / Carcinoma de Células Escamosas / Carcinoma de Células de Transição / Adenocarcinoma Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: World J Urol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Uretrais / Carcinoma de Células Escamosas / Carcinoma de Células de Transição / Adenocarcinoma Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: World J Urol Ano de publicação: 2016 Tipo de documento: Article País de afiliação: Alemanha