Therapeutic superiority of combined propranolol with short steroids course over propranolol monotherapy in infantile hemangioma.
Eur J Pediatr
; 174(11): 1503-9, 2015 Nov.
Article
em En
| MEDLINE
| ID: mdl-25982338
ABSTRACT
UNLABELLED Infantile hemangiomas are the most common benign childhood tumor that may have functional and/or cosmetic complications. We aimed to compare the clinical efficacy of propranolol alone and propranolol primed with systemic corticosteroids on the outcome of infantile hemangioma. A prospective randomized study included 40 infants aged less than 9 months with cutaneous hemangiomas. Patients were randomly assigned into two groups group A were given oral prednisolone for the initial 2 weeks combined with oral propranolol, while group B were given oral propranolol alone for 6 months. The median age of the studied patients was 4.5 months (ranged 4 weeks-8 months). Sequential determination of the dimensions of the hemangiomas based on direct measurement and photographic analysis were performed. A significant reduction in the size of the lesions was found in group A in the 2-, 4-, and 8-week evaluation compared to group B (p < 0.001) with no statistical difference in the ultimate 6 month response (p = 0.134). Multiple logistic regression showed that early treatment before 6 months of age (OR 9.82, p = 0.007) and combined treatment with propranolol and prednisolone (OR 10.71, p = 0.006) were the predictors of best response. CONCLUSION:
Combining propranolol with corticosteroids gives a faster response and should be considered in treating life- or function-threatening hemangiomas.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propranolol
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Neoplasias Cutâneas
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Prednisolona
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Antagonistas Adrenérgicos beta
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Glucocorticoides
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Hemangioma
Tipo de estudo:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Eur J Pediatr
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Egito